Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
Journal: Developmental Cell Publication year: 2020
This is a really cool paper that shows that β-catenin-mediated regulation of transcription occurs at the earliest stages of embryonic development in which the zygotic genome is activated. No Wnt ligand is required for the stabilization and subsequent accumulation of β-catenin. Instead, maternal zygotic tankyrase (a poly-ADP-ribosyltransferase) is developmentally programmed to be upregulated at the translational level. Tankyrase parylates Axin, a key component of the β-catenin destruction complex, which results in Axin polyubiquitination and proteosomal degradation. As Axin is a limiting essential component of the β-catenin destruction complex, a species of β-catenin capable of regulating transcription of target genes such as c-Myc is generated, which enables appropriate embryonic genome activation.